The last game that was played in London was very exciting as the Minnesota Vikings played the Pittsburgh Steelers. I don't think this game between the Jacksonville Jaguars and the San Francisco 49ers will be as interesting. The Jacksonville Jaguars are a dud this year and are obviously not going to be in the playoffs. San Francisco is much better than the Jaguars and has a good chance to make it to the Wild Card spot in the NFC.
The London crowd will most likely be rooting for the Jacksonville Jaguars. The Jaguars have a deal to be the home team there in London for one game a season for the next four years, and I think the crowd will cheer for them to help get their spirits up. If the Jaguars want to win, they will basically have to do everything possible to get better and play an almost perfect game. The Jaguars offense is not good enough to even get one touchdown against the 49ers, and I don't think their defense can put a stop to Colin Kaepernick and the running game of San Francisco.
It would be nice if the Jacksonville Jaguars can surprise the London crowd and all of us by getting a win, but ultimately I think the San Francisco 49ers win this game 49-3.