| WEEK 1 |
| Thursday, September 4, 2008 |
 |  | Washington Redskins@
New York Giants | 7:00 pm ET |  |
| Sunday, September 7, 2008 |
 |  | Jacksonville Jaguars@
Tennessee Titans | 1:00 pm ET |  |
 |  | Houston Texans@
Pittsburgh Steelers | 1:00 pm ET | |
 |  | St. Louis Rams@
Philadelphia Eagles | 1:00 pm ET |  |
 |  | Tampa Bay Buccaneers@
New Orleans Saints | 1:00 pm ET | |
 |  | Kansas City Chiefs@
New England Patriots | 1:00 pm ET | |
 |  | New York Jets@
Miami Dolphins | 1:00 pm ET | |
 |  | Seattle Seahawks@
Buffalo Bills | 1:00 pm ET | |
 |  | Cincinnati Bengals@
Baltimore Ravens | 1:00 pm ET | |
 |  | Detroit Lions@
Atlanta Falcons | 1:00 pm ET | |
 |  | Arizona Cardinals@
San Francisco 49ers | 4:15 pm ET | |
 |  | Carolina Panthers@
San Diego Chargers | 4:15 pm ET | |
 |  | Dallas Cowboys@
Cleveland Browns | 4:15 pm ET | |
 |  | Chicago Bears@
Indianapolis Colts | 8:15 pm ET | |
| Monday, September 8, 2008 |
 |  | Minnesota Vikings@
Green Bay Packers | 7:00 pm ET |  |
 |  | Denver Broncos@
Oakland Raiders | 10:15 pm ET | |
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