| WEEK 4 |
| Thursday, August 28, 2008 |
 |  | Detroit Lions@ Buffalo Bills | 6:30 pm ET | |
 |  | New York Jets@ Philadelphia Eagles | 6:30 pm ET | |
 |  | Atlanta Falcons@ Baltimore Ravens | 7:00 pm ET | |
 |  | New England Patriots@ New York Giants | 7:00 pm ET | |
 |  | Carolina Panthers@ Pittsburgh Steelers | 7:00 pm ET | |
 |  | St. Louis Rams@ Kansas City Chiefs | 7:00 pm ET | |
 |  | Tennessee Titans@ Green Bay Packers | 7:00 pm ET | |
 |  | Cincinnati Bengals@ Indianapolis Colts | 7:00 pm ET | |
 |  | Jacksonville Jaguars@ Washington Redskins | 7:00 pm ET |  |
 |  | Chicago Bears@ Cleveland Browns | 7:30 pm ET | |
 |  | Tampa Bay Buccaneers@ Houston Texans | 8:00 pm ET | |
 |  | Minnesota Vikings@ Dallas Cowboys | 8:00 pm ET | |
 |  | Miami Dolphins@ New Orleans Saints | 8:00 pm ET | |
| Friday, August 29, 2008 |
 |  | San Diego Chargers@ San Francisco 49ers | 10:00 pm ET | |
 |  | Denver Broncos@ Arizona Cardinals | 10:00 pm ET | |
 |  | Oakland Raiders@ Seattle Seahawks | 10:00 pm ET | |