| WEEK 3 |
| Thursday, August 21, 2008 |
 |  | San Francisco 49ers@ Chicago Bears | 8:00 pm ET |  |
| Friday, August 22, 2008 |
 |  | Philadelphia Eagles@ New England Patriots | 7:30 pm ET | |
 |  | Tennessee Titans@ Atlanta Falcons | 7:30 pm ET | |
 |  | Houston Texans@ Dallas Cowboys | 8:00 pm ET |  |
 |  | Green Bay Packers@ Denver Broncos | 9:00 pm ET | |
| Saturday, August 23, 2008 |
 |  | Cleveland Browns@ Detroit Lions | 4:00 pm ET | |
 |  | New York Giants@ New York Jets | 7:00 pm ET | |
 |  | Washington Redskins@ Carolina Panthers | 7:30 pm ET | |
 |  | Jacksonville Jaguars@ Tampa Bay Buccaneers | 7:30 pm ET | |
 |  | Kansas City Chiefs@ Miami Dolphins | 7:30 pm ET | |
 |  | New Orleans Saints@ Cincinnati Bengals | 7:35 pm ET | |
 |  | Pittsburgh Steelers@ Minnesota Vikings | 8:00 pm ET |  |
 |  | Baltimore Ravens@ St. Louis Rams | 8:00 pm ET | |
 |  | Arizona Cardinals@ Oakland Raiders | 9:00 pm ET | |
| Sunday, August 24, 2008 |
 |  | Buffalo Bills@ Indianapolis Colts | 8:00 pm ET |  |
| Monday, August 25, 2008 |
 |  | Seattle Seahawks@ San Diego Chargers | 8:00 pm ET |  |