| WEEK 2 |
| Thursday, August 14, 2008 |
 |  | Pittsburgh Steelers@ Buffalo Bills | 7:30 pm ET | |
 |  | Carolina Panthers@ Philadelphia Eagles | 8:00 pm ET |  |
| Friday, August 15, 2008 |
 |  | Oakland Raiders@ Tennessee Titans | 8:00 pm ET |  |
| Saturday, August 16, 2008 |
 |  | Washington Redskins@ New York Jets | 7:00 pm ET | |
 |  | Indianapolis Colts@ Atlanta Falcons | 7:30 pm ET | |
 |  | Minnesota Vikings@ Baltimore Ravens | 7:30 pm ET | |
 |  | Miami Dolphins@ Jacksonville Jaguars | 7:30 pm ET | |
 |  | Arizona Cardinals@ Kansas City Chiefs | 8:00 pm ET | |
 |  | San Diego Chargers@ St. Louis Rams | 8:00 pm ET | |
 |  | Houston Texans@ New Orleans Saints | 8:00 pm ET | |
 |  | Dallas Cowboys@ Denver Broncos | 9:00 pm ET | |
 |  | Chicago Bears@ Seattle Seahawks | 9:00 pm ET | |
 |  | Green Bay Packers@ San Francisco 49ers | 9:00 pm ET | |
| Sunday, August 17, 2008 |
 |  | Detroit Lions@ Cincinnati Bengals | 7:35 pm ET | |
 |  | New England Patriots@ Tampa Bay Buccaneers | 8:00 pm ET |  |
| Monday, August 18, 2008 |
 |  | Cleveland Browns@ New York Giants | 8:00 pm ET |  |